The Seth McFarlane created animated sitcom has worn its rainbow pride on its shoulder before but tonight it goes all the way. The Seth McFarlane created animated sitcom has worn its rainbow pride on its shoulder before but tonight it goes all the way. The episode, titled Family Gay, premieres on Fox tonight, Sunday, March 8. A Fox press release about the episode described the premise of the show: “To help pay off his incredible debt, Peter participates in medical experiments to make some extra cash. First, he is injected with the 'Seth Rogen' gene that 'gives you the appearance of being funny even though you haven't actually done anything funny'. Then he is injected with a gene that leads him to a new mate, leaving a broken-hearted Lois behind. Although the family is crushed, they quickly realize the most important thing is that Peter is happy.” McFarlane first talked about the gay-themed episode in an interview with gay monthly The Advocate last year. Special guest-voice by Seth Rogen (Zack and Miri Make a Porn) as the “Seth Rogen” gene.

"ER"'s ratings heartrate spiked Thursday night as George Clooney made his higly anticipated return to the show. Clooney's appearance as Dr. Doug Ross delivered the medical drama it's best viewership ratings in two years, says Reuters. The star departed the show in 1999 to pursue his movie career. "ER" is now in its final season.

The eighth season finale of "Smallville," which will leave two dead, is currently filming in Vancouver, and ET talked to Cassidy Freeman to find out who will bite the dust! "It is very hush-hush," the actress who plays Tess Mercer tells ET. "They only give you your scenes, but they won't tell you what is going on." "Smallville" will be returning for a ninth season. The hit series was given an early pickup when Tom Welling agreed to sign on for another season as Clark Kent. His is the one character who is safe. And, according to Freeman, the Justice League will be back. But that is all she can say, although one death is alleged to be a long-running character. "They are not even telling us," she says. "They are holding off as long as they can [letting us know] who is coming back next year. The show is going into season nine. I don't know if Tess Mercer is going into season nine." The title of the finale, airing on May 13, is "Doomsday," which could indicate a final fight between Clark and Doomsday.

Viewers of last night's episode of the FOX doctor drama "House" know that actor Kal Penn departed the show in a shocking twist. Now find out why he is taking a break from acting to work for President Barack Obama. Penn, whose character Dr. Lawrence Kutner committed suicide in the episode, tells Entertainment Weekly that he decided himself to leave the show so he could spend time working on his other career passion. "I was incredibly honored a couple of months ago to get the opportunity to go work in the White House. I got to know the president and some of the staff during the campaign and had expressed interest in working there, so I'm going to be the associate director in the White House Office of Public Liaison," Penn tells the magazine. He said his new position will focus on doing outreach activities to help connect the general public and the White House. "I've been thinking about [moving into politics] for a while. I love what I do as an actor. I couldn't love it more. But probably from the time I was a kid, I really enjoyed that balance between the arts and public service."

Benjamin McKenzie marks his return to TV tonight in "Southland," a gritty police drama set in Los Angeles. Ben, who last played the Ryan Attwood, a down-on-his-luck kid who is taken in by Sandy Cohen (Peter Gallagher) on "The O.C.," now plays the opposite side of the coin. His new character, Ben Sherman is a rich kid who forsakes college to join the L.A.P.D. "I've always thought of him as someone who is incredibly ambitious, who is incredibly focused and wants to leave his mark," the Texas-born actor says. "He chose to start off in law enforcement at the street level in order to go his own way. His father [a high-powered defense attorney] is doing something that is almost completely antithetical to what he is doing." "Southland," from Emmy Award-winning producers John Wells, Ann Biderman and Chris Chulack is a raw and authentic look at a police unit in Los Angeles that takes viewers inside the lives of cops, criminals, victims and their families. To give the series its sense of reality, Chick Daniel, an ex-LAPD, ex-SWAT officer, and Sheila Daniel, also ex-LAPD, were hired as technical advisors and to train the actors. "We've hung out a lot with cops," Ben adds. "Chick and Sheila walked us through all sorts of things -- handcuffing, we went to the gun range, fired the weapons that are appropriate for our characters. We've also had the opportunity to do ride-alongs with cops all over L.A. from the valley to Hollywood to southeast and south metro L.A." "Southland" also stars Michael Cudlitz as John Cooper, a seasoned Los Angeles cop assigned to train young rookie Ben Sherman, Regina King, Tom Everett Scott and Shawn Hatosy. "Hopefully, this show will capture the zeitgeist at the moment, which is a little dark. We're in a tough time economically. L.A. is not immune from that," Ben says. "L.A. is, in my view, the quintessential American city of the 21st Century in that it's big, crazy and wild. You have extreme wealth knocking up against extreme poverty, and you have all sorts of ethnicities and cultures represented. L.A. is the perfect place to set a show like this."

Lo Bosworth may not want to see her best friend Lauren Conrad leave The Hills, but she does think the series can survive without her. In fact, Lo thinks Heidi Montag and Spencer Pratt could probably replace Ms. Conrad as the MTV reality show's headlining act. "They get great press on their own, so there's always the possibility that the show can do really well with them as main parts," Bosworth told us last night at the IS vodka-sponsored opening of new Hollywood nightspot Halo. Lo thinks, however, that season five may not end all L.C. appearances on The Hills... "[Lauren] hasn't filmed in weeks and she's really excited about that," Lo said. "I think she'll come back for special occasions and stuff, but we just don't know how many episodes she'll return for or if there will be another season. It's really just all up in the air." If Speidi does become the main attraction, a title change may be in order. Forget The Hills! Don't you think Divorce Court sounds so much more fun?

"Desperate Housewives" actress Nicollette Sheridan tells TV Guide Magazine that killing off her character, Edie Britt, could have "devastating ramifications" for the show. She tells the publication of her character's relationship with the show's creator Marc Cherry, "I think whoever Edie represented in Marc's life was somebody he didn't like. And he had a very difficult time distinguishing between fact and fiction." Nicollette says, for her, "Desperate Housewives" started to change. "When the show started it was such a different beast. It was exciting and dangerous and funny and edgy and bizarre. It started feeling a little complacent, and that was very frustrating." Marc says the show has been having financial troubles and according to TV Guide Magazine, cutting Nicollette will save the show $100-$200,000 an episode. "There has been tremendous pressure put on me to cut costs…the network is saying to all the shows, 'The company is really hurting financially. You must find a way to produce these shows more cheaply,'" he tells TV Guide Magazine. He continues, "Edie already slept with most of the guys on the street and has caused about as many problems as she could. … We will find a new kind of sexiness coming through Wisteria Lane. What I won't do is cast another fortysomething sexy blonde. … [Nicollette] performed the aging neighborhood tramp better than anyone has ever done before."

ET confirms that the nail-biting FOX drama "24" is heading to the Big Apple next season. The onscreen switch to New York will not change the fact that most of the series will still be shot in Los Angeles, a rep for FOX said. In addition to the location shift, the CTU anti-terror unit featured in the show will be lead by a new, yet-to-be-cast male character named Brian Hastings, according to FOX. Kiefer Sutherland portrays special agent Jack Bauer on the show, which each season takes viewers on an action-packed ride during episodes spanning a consecutive 24-hour period. The series is set to start shooting its eighth season next month.

Thank you, Dana Delaney. The Desperate Housewives star hit the red carpet for the 20th Annual GLAAD Media Awards tonight in Los Angeles and was in quite a gossipy mood. Dana confirmed a few Wisteria Lane rumors that have been floating around for the past two days, and here's how it went down. [Don't read past the jump if you don't want it spoiled.] We hear your character, Katherine, might be pregnant on the show. Is that true? I heard that one today too. I think that would be really a miracle if I got pregnant. I do know that Mike [James Denton] and I have a romantic announcement. You and Mike are getting engaged? Possibly. But, aren't Susan [Teri Hatcher] and Jackson [Gale Harold] getting engaged? Yep. And, Katherine and Mike are getting engaged too? Yep. So, that's a yes to you're both getting engaged? Yes. I hope I don't get in trouble. How does your proposal go down? It's funny the way it goes down. Let's say that Katherine knows what she's doing. Wait, do you propose to him? [She gave us a coy look, raised her eyebrows and laughed.] I'll take that as a maybe. Actually, the proposal is very Mike-like. That's all I'll say. Before you get too excited, consider this: Just because there are two proposals doesn't necessarily mean there will be two answers of "yes" to those proposals or two weddings. We caught up with Teri Hatcher at the Desperate Housewives Paley Fest panel on Saturday afternoon and asked her if she says "yes" to Jackson's proposal, and she told us, "I can't tell you that." But she did dish this: "The first scene where [Gale's] back on the street is really spicy. It was really great to see him again and I think all that came across on film, so it's great to have him back." If Susan and Jackson do get hitched, show creator Marc Cherry might end up putting a wrench in their happiness down the road. On the topic of Susan and Mike getting back together, Marc told the Paley audience, "The idea is we'll get back there. I don’t know when. If ABC makes a deal with all of us, it looks like we have a few years to play this out, so I would imagine at some point in time Susan and Mike will find their way back in each other's universe. Denton hopes to be back in Hatcher's universe sometime soon too. He tells us, "I loved working with Teri for the first four seasons and hopefully will continue to. I think in the big picture, most people hope Mike and Susan will make their way back around to each other, but right now it’s Mike and Katherine. Mike and Katherine are a weird couple which is kind of fun, but it makes sense because Katherine is the anti-Susan. She's very stable, there's no drama, so it's easy to see why Mike is drawn to her." What do you think of the two potential engagements? Do you like these couples, or do you hope that Susan and Mike will find their way back to each other one day?

ABC announced early pickups for its 2009-2010 season, and "Ugly Betty," which many felt was in danger of cancellation, got the green light for a fourth season. Fans of "America's Funniest Home Videos," "The Bachelor," "Brothers & Sisters," "Dancing with the Stars," "Desperate Housewives," "Extreme Makeover: Home Edition," "Grey's Anatomy," "Lost," "Private Practice," "Supernanny," and "Wife Swap" can also breathe a sigh of relief, as these shows were also given early pickups.

Meredith Grey may have wanted an intimate and understated wedding, but her pal Izzie is determined to make sure her friend is a beautiful bride in a big white dress. Even though she is going through chemo on Grey’s Anatomy, Izzie is still planning Meredith’s wedding to on-again fiancé, neurosurgeon Derek Shepherd. To assist, ABC’s marketing department has created a Web site for the couple, built within Theknot.com. The site celebrates Meredith and Derek’s relationship and includes categories labeled “The Couple,” “The Proposal,” and “The Dresses” — complete with pictures and commentary from Izzie. “I know I know. I secretly never thought it would happen either,” Izzie says on the welcome page. “But it’s real. This is going to be the most magical, romantic, breathtaking wedding you’ve ever seen. I promise.” The site has been up since last week’s episode aired Thursday and already has more than 42,000 unique views. There’s even a gift registry. Fans of Mer and Der are encouraged to donate money to The American Academy of Neurology Foundation, the American Skin Association, and the Alzheimer’s Association — all charities that have a connection to Grey’s storylines. But one big question remains: Will Mer and Der actually say “I do?” “You may be surprised at the way we bring it off,” Grey’s creator and executive producer Shonda Rimes told the AP. “But at the end of the season viewers will be very happy with where Meredith and Derek are.”

Jeffrey Dean Morgan says he will be back for one more episode of "Grey's Anatomy." "I can confirm that I will be coming back one more time," the actor told EW magazine at Thursday night's 'Star Trek' premiere. "I think it will be done after that. I think I have been on the 'Grey's Anatomy' set for the last time." Izzie (Katherine Heigl) began seeing her dead boyfriend, Denny (Morgan), at the beginning of this season of the hit ABC doctor drama. He told her "he was back for her," and it took her awhile to figure out that that meant he was warning her she was at death's door with a fatal disease. Once Izzie figured out she was suffering from skin cancer, Denny disappeared, but it appears likely that he will be back for the 100th episode of the series, which is the episode in which Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) are supposed to take a walk down the aisle.

NBC announced today that its 2009-2010 schedule will include four new dramas and two new comedies. Read on to find out if your favorite shows are coming back! The new dramas are "Parenthood," "Trauma," "Mercy" and the limited run series "Day One." The two comedies are "Community" and "100 Questions." Return series that received a pickup are "Heroes," "Southland," "Parks and Recreation," as well as six new episodes of "Saturday Night Live Weekend Update Thursday." These join the previously announced "The Office," "30 Rock," "The Biggest Loser," "The Celebrity Apprentice," "Law & Order: Special Victims Unit," "Friday Night Lights," and new alternative series "The Marriage Ref," "Breakthrough With Tony Robbins" and "Who Do You Think You Are?" Also, "The Jay Leno Show" will be broadcast Monday-Fridays, 10-11 p.m. ET beginning in the fall. Several series are still on the cusp, including "Chuck," "Law & Order," "Medium" and "My Name Is Earl." The peacock network said it will announce additional pickups and renewals on May 19, when it holds a comedy event for advertisers. "We are thrilled to be announcing such an awesome slate of new series that build on our existing quality brand and deliver emotional, human stories," said Ben Silverman, co-chairman, NBC Entertainment and Universal Media Studios. "NBC will strive to make viewers feel and our shows represent the full range of human emotion from laughter to tears. We can't wait to share these concepts with our audience and our advertising partners."

Last week on "Grey's Anatomy," Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) gave their wedding to Izzie (Katherine Heigl) when it was discovered that she had a new brain tumor. So the question remains, will Mer-Der ever get married? Will Izzie die? ET turns to Matt Roush, TV Guide magazine's senior critic for some answers. "All we know about 'Grey's Anatomy' is almost everybody will be back next season," he says. "Jessica Capshaw will be back full time as Arizona, the lesbian girlfriend of Callie (Sara Ramirez). We don't know if Meredith and Derek are getting married. We don't know if Izzie is going to die. We don't know if George (T.R. Knight) is going to leave." "This could be one way of cutting costs," says Entertainment Weekly's Jennifer Armstrong. "It's also possible that they're even faking us out on purpose." What we do know is Izzie spends time with a fellow cancer patient and contemplates whether or not to undergo a risky surgery, as Mark (Eric Dane) is ready to take his relationship with Lexie (Chyler Leigh) to the next level, and a patient makes Owen (Kevin McKidd) reassess his place at Seattle Grace. "Owen is tortured. He is trying to get past his post traumatic stress demons," Matt adds.

Chad Michael Murray no longer married to One Tree Hill. The triple-named actor, along with fellow original castmember Hilarie Burton, will not be returning for the series' seventh season next fall, the CW confirms to E! News. No formal reason was given for the departure of the stars, though the duo had been in protracted contract negotiations with the network for several months. The CW said that two new characters will be introduced next season in an attempt to placate fans and rebuild the call sheet. Murray and Burton have been with the show since its 2003 debut on the WB. Writers have wrapped up the storylines of characters Peyton and Lucas rather nicely: The duo tied the knot in last night's episode, and will make their final appearance on next Monday's season finale. Their departure was first reported by EW.com. Overall, it hasn't been the best month, PR-wise, for the extended Murray clan. Just last month, his fiancée's sister, Kristen Dalton, was crowned Miss USA, only to be dramatically overshadowed by a certain runner-up, name of Carrie Prejean.

"Grey's Anatomy" creator and head writer Shonda Rhimes is talking about the fates of Izzy, George and the Post-It wedding. Speaking to Entertainment Weekly, the Emmy nominee hints at what lies beyond Thursday's night's big finale (see the ET recap if you missed it). Responding to rumors that both Katherine Heigl and T.R. Knight asked to be released from their contracts and leave the show, Shonda says, "I think Katherine's stated publicly that she's happy to stay. I think that there have been lots of rumors about T.R., but T.R.'s never said anything. Take from it what you will." She dispels the idea that this season's ending playing off those rumors to generate buzz for the show, however coincidental that may be. "Every year at the beginning of the season I pitch what the end of the season is going to be," she says. "I literally sat down and pitched the last 10 minutes of this season at the beginning of the season, so we were headed towards the place that we knew we were going to go." When asked if George or Izzy lives, she replies coyly, "I don't know that you should be saying 'which one of them lives and which one of them dies.' I know what happens to the characters." Meanwhile, on the subject of Meredith and Derek, Shonda believe she gave the viewers what they wanted while staying true to the characters. "Their wedding was a Post-it note," she says. We had a big series of discussions about it in the writers' room. I felt very strongly -- very very strongly -- that the last thing Meredith Grey would do is put on a wedding dress and walk down an aisle. It just felt wrong to me, Meredith being Meredith. And the Post-it wedding will have big reverberations next season."

The "NCIS" team heads to Tel Aviv for an explosive season finale -- and ET's Kevin Frazier has your sneak peek from the cast! "As always, it is complicated," series star Mark Harmon, who plays Leroy Jethro Gibbs, tells Kevin. "There is a fight and more issues come out. What you see is not entirely what you get." On last week's episode, Tony (Michael Weatherly) had a confrontation with Michael Rivkin, who is romantically involved with Ziva (Cote de Pablo), and who may also be an assassin. Michael was sent to the U.S. by Ziva's father, Mossad director Eli David (Michael Nouri), and now the team heads to Tel Aviv for a final showdown. Ziva's homecoming is not a happy reunion with her father, and it also puts her relationship with Tony in jeopardy. "The relationship that changes dramatically is my relationship with Tony," Cote reveals. And Michael agrees, adding, "The relationship is in tatters." Then, Gibbs is forced to make a decision that sends shockwaves through NCIS. "Let's just say someone on this team is in jeopardy of not coming back," Cote teases.

The living-on One Tree Hill rode Chad Michael Murray and Hilarie Burton off into the sunset Monday night before 2.7 million well-wishers, per preliminary Nielsen estimates. The show's audience was up more than 20 percent over last week. Elsewhere in last night's ratings: • Season-finale season or no, a bunch of shows had down nights, including Dancing With the Stars (18.7 million—off 2 million from last week), 24 (9.4 million) and How I Met Your Mother (8.7 million). • Gossip Girl threw a graduation—and ran even with last week: 2.2 million. • Two and a Half Men knows how to close out a season: 16 million viewers, up nearly 2 million over last week. CSI: Miami (14 million) also was up. • The Bachelorette premiere scored an OK 9 million, up from last spring's opener.

The Disney Channel has ordered a fourth season of its hit series "Hannah Montana," starring teen sensation Miley Cyrus. Production on the show's current season is wrapping this week and shooting will resume early next year, the cable channel announced Monday. In announcing the decision, a statement said: "Miley and the producers have proposed a change of setting for Season Four that will provide the catalyst for wonderful new characters and further expand the storytelling opportunities." The popular series was also made into a film, 'Hannah Montana: The Movie,' which launched in April. The movie won Miley an MTV award for Best Song, "The Climb," which was presented to her last night at the 2009 MTV Movie Awards.

Actors from the hit shows "Grey's Anatomy" and "The Big Bang Theory" are announcing the nominations for the "61st Primetime Emmy Awards Nominations" to their fellow TV stars. Chandra Wilson, who plays Dr. Miranda Bailey on "Grey's," and Jim Parsons, who plays Sheldon Cooper on "Big Bang," will reveal the nominations on Thursday, July 16. ET reported on Monday that the Emmy Awards would be moving ahead a week due to CBS' NFL football coverage. This year's awards ceremonies will move from Sunday, Sept. 20 to Sunday, Sept. 13.